Near infrared light decreases synaptic vulnerability to amyloid beta oligomers
نویسندگان
چکیده
منابع مشابه
Vulnerability of small GABAergic neurons to human beta-amyloid pentapeptide.
beta-Amyloid peptide (A beta), the principal component of senile plaques in Alzheimer's disease, has been found to be neurotoxic. The role of A beta in the deficits of the GABAergic system in patients with Alzheimer's disease is unclear. It has been suggested that the cytotoxic activity of A beta is localized to amino acid residues 25-35 of this peptide, which contains a total of 42 amino acid ...
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Pascale N. Lacor,1 Maria C. Buniel,1 Lei Chang,1 Sara J. Fernandez,1 Yuesong Gong,1 Kirsten L. Viola,1 Mary P. Lambert,1 Pauline T. Velasco,1 Eileen H. Bigio,2 Caleb E. Finch,3 Grant A. Krafft,4 and William L. Klein1 1Neurobiology and Physiology Department, Northwestern University, Evanston, Illinois 60208, 2Neuropathology Core, Northwestern Alzheimer’s Disease Center, Northwestern Feinberg Sch...
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We achieved photoacoustic ophthalmoscopy (PAOM) imaging of the retina with near-infrared (NIR) light illumination. A PAOM imaging system with dual-wavelength illumination at 1064 nm and 532 nm was built. We compared in vivo imaging results of both albino and pigmented rat eyes at the two wavelengths. The results show that the bulk optical absorption of the retinal pigment epithelium (RPE) is on...
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Recent studies have indicated an association between Alzheimer's disease (AD) and central nervous system (CNS) insulin resistance. However, the cellular mechanisms underlying the link between these two pathologies have not been elucidated. Here we show that signal transduction by neuronal insulin receptors (IR) is strikingly sensitive to disruption by soluble Abeta oligomers (also known as ADDL...
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Alzheimer-disease-associated beta-amyloid (Abeta) is produced by sequential endoproteolysis of beta-amyloid protein precursor (betaAPP): the extracellular portion is shed by cleavage in the juxtamembrane region by beta-amyloid-cleaving enzyme (BACE)/beta-secretase, after which it is cleaved by presenilin (PS)/gamma-secretase near the middle of the transmembrane domain. Thus, inhibition of eithe...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2017
ISSN: 2045-2322
DOI: 10.1038/s41598-017-15357-x